The influence of a polymorphism in the gene encoding angiotensin converting enzyme (ACE) on treatment outcomes in late-onset Pompe patients receiving alglucosidase alfa

نویسندگان

  • Rena C. Baek
  • Rachel Palmer
  • Robert J. Pomponio
  • Yuefeng Lu
  • Xiwen Ma
  • Alison J. McVie-Wylie
چکیده

Correlations between angiotensin-converting enzyme (ACE) genotype (I/I, I/D, D/D), disease severity at baseline and response to enzyme replacement therapy (ERT) were assessed in the Pompe disease Late-Onset Treatment Study (LOTS). No correlations were observed between ACE genotype and disease severity at baseline. However, D/D patients appeared to have a reduced response to alglucosidase alfa treatment than I/I or I/D patients, suggesting that ACE polymorphisms may influence the response to alglucosidase alfa treatment and warrants further investigation.

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عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2016